This is the third edition of a classic book first published in 1960, which has sold thousands of copies in two paperback edition and has been translated into several foreign languages. Popkin's work ha generated innumerable citations, and remains a valuable stimulus to current historical research. In this updated version, he has revised and expanded throughout, and has added three new chapters, one on Savonarola, one on Henry More and Ralph Cudworth, and one on Pascal. This authoritative treatment of the (...) theme of scepticism and its historical impact will appeal to scholars and students of early modern history now as much as ever. (shrink)

Richard Popkin has assembled 63 leading scholars to forge a highly approachable chronological account of the development of Western philosophical traditions. From Plato to Wittgenstein and from Aquinas to Heidegger, this volume provides lively, in-depth, and up-to-date historical analysis of all the key figures, schools, and movements of Western philosophy. The Columbia History significantly broadens the scope of Western philosophy to reveal the influence of Middle Eastern and Asian thought, the vital contributions of Jewish and Islamic philosophers, and the (...) role of women within the tradition. Along with a wealth of new scholarship, recently discovered works in 17th- and 18th-century philosophy are considered, such as previously unpublished works by Locke that inspire a new assessment of the evolution of his ideas. Popkin also emphasizes schools and developments that have traditionally been overlooked. Sections on Aristotle and Plato are followed by a detailed presentation on Hellenic philosophy and its influence on the modern developments of materialism and scepticism. A chapter has been dedicated to Jewish and Moslem philosophical development during the Middle Ages, focusing on the critical role of figures such as Averroës and Moses Maimonides in introducing Christian thinkers to classical philosophy. Another chapter considers Renaissance philosophy and its seminal influence on the development of modern humanism and science. Turning to the modern era, contributors consider the importance of the Kaballah to Spinoza, Leibniz, and Newton and the influence of popular philosophers like Moses Mendelssohn upon the work of Kant. This volume gives equal attention to both sides of the current rift in philosophy between continental and analytic schools, charting the development of each right up to the end of the 20th century. Each chapter includes an introductory essay, and Popkin provides notes that draw connections among the separate articles. The rich bibliographic information and the indexes of names and terms make the volume a valuable resource. Combining a broad scope and penetrating analysis with a keen sense of what is relevant for the modern reader, _The Columbia History of Western Philosophy_ will prove an accessible introduction for students and an informative overview for general readers. (shrink)

Public health is concerned with increasing the health of the community at whole. Insofar as health is a ‘good’ and the community constitutes a ‘public’, public health by definition promotes a ‘public good’. But ‘public good’ has a particular and much more narrow meaning in the economics literature, and some commentators have tried to limit the scope of public health to this more narrow meaning of a ‘public good’. While such a move makes the content of public health less controversial, (...) it also strips important goals from the realm of public health, goals that traditionally have been, and morally should be, a part of it. Instead, I will argue, while public health should be defined by public goods, it should be defined by a broader conception of public goods that I shall call ‘normative public goods’, goods that ought to be treated as if they were public goods in the more narrow sense. (shrink)

: The idea of enhancing our mental functions through medical means makes many people uncomfortable. People have a vague feeling that altering our brains tinkers with the core of our personalities and the core of ourselves. It changes who we are, and doing so seems wrong, even if the exact reasons for the unease are difficult to define. Many of the standard arguments against neuroenhancements—that they are unsafe, that they violate the distinction between therapy and enhancements, that they undermine equality, (...) and that they will be used coercively—fail to show why the use of any such technologies is wrong in principle. Two other objections—the arguments that such changes undermine our integrity and that they prevent us from living authentic lives—will condemn only a few of the uses that are proposed. The result is that very few uses of these drugs are morally suspect and that most uses are morally permissible. (shrink)

David Hume is an ardent supporter of the practice of religions toleration. For Hume, toleration forms part of the background that makes progress in philosophy possible, and it accounts for the superiority of philosophical thought in England in the eighteenth century. As he puts it in the introduction to the Treatise: “the improvements in reason and philosophy can only be owing to a land of toleration and of liberty” (T Intro.7; SBN xvii).1 Similarly, the narrator of part 11 of the (...) First Enquiry comments: -/- Our conversation began with my admiring the singular good fortune of philosophy, which, as it requires entire liberty above all other privileges, and chiefly flourishes from the free opposition of sentiments and argu­ mentation, received its first birth in an age and country of freedom and toleration. (EHU 11.2; SBN 132) -/- The toleration to which Hume refers is broader than religious toleration, but in the context of the eighteenth century, religious toleration is clearly the paradigm case. Indeed, religious toleration represents one of the key accomplishments of the culminating event of Hume’s History of England: the Glorious Revolution of 1688. -/- Yet even though religious toleration forms the background of philosophy in general—or perhaps just because it does so—Hume offers precious few arguments for it, and they are, for the most part, given implicitly rather than as formal argu­ ments. Nevertheless, we can distinguish three different, though interrelated, lines of support for toleration in Hume’s thought: (i) an argument based on a general skepticism; (ii) an argument based on a contempt for organized religion; and (iii) a pragmatic argument based on the need for peace and orderly government. From our point of view, what is striking about all of these argument is how un-Lockean they are: Hume does not rely on the idea of a fundamental conceptual separation of church and state, nor on a natural right to freedom of conscience that character­izes writers working in the Lockean tradition. However, of the arguments he gives, only the last, I will argue, has any hope to provide a useful case for toleration. (shrink)

Wittgenstein, in his characteristic way of indirectly bringing us to see an important feature in human life, said: ‘… art shows us the miracles of nature… We say: “Just look at it opening out!” This essay discusses how works of art ‘blossom’ and thus elicit an imaginative human response. Its various parts focus on the connected theme that some sensible component is essential to the production and comprehension of art. Each part, however, investigates a different aspect of the theme and (...) could stand on its own. What will be argued about this aesthetic factor in art will also be shown to cast light on our understanding of certain narrative texts and ceremonial acts of religion. (shrink)

Liberals often assume that once people see the costs of intolerance that they will come to embrace toleration and that once they can accept toleration as a modus vivendi, they will soon be able to see it as a good in its own right. But, I argue, that the logic that make in tolerance difficult to break also compel people to resist any attempts to make toleration more than a modus vivendi. True toleration will not be embraced unless the people (...) undergo a kind of conversion experience. (shrink)

After a long search, Jonathan has finally found someone willing to donate a kidney to him and thereby free him from dialysis. Meredith is Jonathan's second cousin, and she considers herself a generous person, so although she barely knows Jonathan, she is willing to help. However, as Meredith learns more about the donation process, she begins to ask questions about Jonathan: “Is he HIV positive? I heard he got it using drugs. Has he been in jail? He's already had one (...) live donor, so what happened to the first kidney? Did he forget to take his drugs or something?” The transplant center must, then, decide if Meredith is, in fact, entitled to answers to these kinds of questions. According to the Consensus Statement on the Live Organ Donor, “It is incumbent on the transplant center to provide full and accurate disclosure to potential donors of all pertinent information regarding risk and benefit to the donor and recipient.” But whether answers to the Meredith's questions count as “pertinent information regarding the risk and benefit” is the issue at hand. (shrink)

The limits of toleration are at the limits of trust. Without a minimal level of trust between different groups, any accommodation will quickly break down (Dees 1999). In many ways, the point here is obvious: people have to trust one another enough to make toleration possible. In other words, they have to feel that their fundamental moral interests are not threatened if they accept toleration. If that trust breaks down, then civil war—in either the hot or the cold variety—will break (...) out. A society built on toleration, then, requires a delicate balance between the practices within it that sustain toleration and those that build the trust between disparate groups. I explore these issues by looking at two groups--the non-Trinitarian Socinians in the 17th century and homosexuals in the 21st--to understand where those boundaries should be. (shrink)

Scientific interest in drug-induced mystical experiences reemerged in the 1990s. This warrants reexamining the philosophical issues surrounding such studies: Do psychedelic drugs cause mystical experiences? Are drug-induced experiences the same in nature as other mystical experiences? Does the fact that mystical experiences can be induced by drugs invalidate or validate mystical cognitive claims? Those questions will be examined here. An overview of the scientific examination of drug-induced mystical experiences is included, as is a brief overview of the history of the (...) use of psychedelic drugs in religion. (shrink)

Few people will easily admit to taking pleasure in the misfortunes of others. But who doesn't enjoy it when an arrogant but untalented contestant is humiliated on American Idol, or when the embarrassing vice of a self-righteous politician is exposed, or even when an envied friend suffers a small setback? The truth is that joy in someone else's pain--known by the German word schadenfreude--permeates our society. In The Joy of Pain, psychologist Richard Smith, one of the world's foremost authorities (...) on envy and shame, sheds much light on a feeling we dare not admit. Smith argues that schadenfreude is a natural human emotion, one worth taking a closer look at, as it reveals much about who we are as human beings. We have a passion for justice. Sometimes, schadenfreude can feel like getting one's revenge, when the suffering person has previously harmed us. But most of us are also motivated to feel good about ourselves, Smith notes, and look for ways to maintain a positive sense of self. One common way to do this is to compare ourselves to others and find areas where we are better. Similarly, the downfall of others--especially when they have seemed superior to us--can lead to a boost in our self-esteem, a lessening of feelings of inferiority. This is often at the root of schadenfreude. As the author points out, most instances of schadenfreude are harmless, on par with the pleasures of light gossip. Yet we must also be mindful that envy can motivate, without full awareness, the engineering of the misfortune we delight in. And envy-induced aggression can take us into dark territory indeed, as Smith shows as he examines the role of envy and schadenfreude in the Nazi persecution of the Jews. Filled with engaging examples of schadenfreude, from popular reality shows to the Duke-Kentucky basketball rivalry, The Joy of Pain provides an intriguing glimpse into a hidden corner of the human psyche. (shrink)

This authoritative new introduction draws on both Richard H. Popkin's unparalleled scholarship and a wealth of historical and philosophical sources to highlight the real influences behind Spinoza's thought. Popkin reconstructs Spinoza the man, and his theories, contrasting these findings with some of the popularity held misconceptions. Locating him within the context of his family and background, the author assesses the impact on Spinoza of everything from his infamous excommunication, to his affection for Euclidian geometry and the work of Descartes. (...) With a full account of Spinoza's groundbreaking Tractatus and Ethics, and an overview of his influence on both of his contemporaries and those who were to folow, this concise survey offers a variety of new perspectives, and will be warmly welcomed by students, scholars and interested readers alike. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Religious Background of Seventeenth-Century Philosophy RICHARD H. POPKIN IT IS AN EXCEEDINGLY GREAT PLEASURE tO participate in the twenty-fifth anniversary issue of the Journal of the Historyof Philosophy.The editor, Professor Makkreel, offered me the opportunity to discuss the rationale for my present research, which I hope has some relevance for future research in the history of philosophy. At a symposium at the American Philosophical Association meeting in (...) Washington in December x985, I argued for taking the historyof philosophy seriously, that is, understanding thinkers and ideas in their actual historical contexts, instead of detaching them into some ahistorical ethereal realm. I argued that one could not make sense of a philosopher's thought detached from his time and circumstances. His ideas could not be understood unless one took account of the language, the usages, the issues and the concerns of the thinker and his time. The all too frequent "reconstruction" of philosophers ' thoughts sees them instead as logical machines, simply moving from clearly stated premises to their logical consequences. As many of us have sought to show, this often grossly distorts what Descartes, Spinoza, Locke, Leibniz and others might have actually thought, and misses much of what they were probably thinking about. I should like to carry this theme further by examining the need to take seriously the religious aspect of philosophizing. I will center on the intellectual scene of the seventeenth century, which I am currently working on though I believe many of the same points could be made about any period in the history of philosophy. Among historians of science there is an ongoing debate about whether the history of the subject should be studied internally or externally. The [:35] 36 JOURNAL OF THE HISTORY OF PHILOSOPHY internalists examine a set of ideas presented by scientist A, and trace their use or development by scientist B. The study that results is primarily the tracing of the course of a set of ideas through a time period. Background data about the scientists, their problems, and their place in society are regarded as of little relevance. The externalists insist that one cannot understand why various questions became important, why various individuals tried to solve them, why they used certain kinds of possible solutions instead of others, etc., unless one knows the external conditions of the time. This has spawned a lot of interesting research into the way scientific studies went on, who supported them, who did them, how they got accepted, and so on. The sociology and even anthropology of science is now a thriving research area, yielding many amazing studies about the scientific world and how it functioned. In so doing, scholars have not just examined the great successful scientists, the Keplers, Galileos, Harveys, and Newtons, but also the small fry, the mediocre, the poor scientists, and even the incompetent ones. They have examined why wrong-headed theories were supported, and accepted, while evidence supporting other theories was readily available. Their concern with the actual course of scientific development as an ongoing part of intellectual history is vital to understanding the scientific world of today, which plays such an overwhelming role in our society. So, some people study the education of the good, the mediocre, the bad scientists; their relative social statuses, incomes, and so on. The religious concerns are, of course, an obvious part of the story from Copernicus to Kepler to Newton to Darwin to Freud to Einstein. The scientists were involved in an ongoing religious world that influenced the role of science. The above named scientists had their religious or irreligious views that were involved with their scientific concerns. And, as we know too well, the impact of their work on religion has been of great importance to the broader intellectual world, and the impact of religion on the acceptance of their science has been and is part of the ongoing intellectual world. This interest amongst historians of science in the sociology, psychology, and anthropology of science has hardly rubbed off on the historians of philosophy. Most of the leading scholars of the last few decades in this work are hardly known and rarely cited in studies in the history of philosophy. We... (shrink)

We focus on the recent non-causal theory of reasons explanationsof free action proffered by a proponent of the agency theory, Timothy O'Connor. We argue that the conditions O'Connor offersare neither necessary nor sufficient for a person to act for a reason. Finally, we note that the role O'Connor assigns toreasons in the etiology of actions results in further conceptual difficulties for agent-causalism.

Many different analyses of the concept of de re belief have been proposed in recent years. Most of these analyses may be called ‘reductionist’ since they attempt to “reduce” de re belief to de dicta belief or to analyze de re belief in terms of de dicta belief. Some reductionist analyses are extremely liberal in their attribution of de re beliefs — they imply that people have de re beliefs in a variety of situations in which more restrictive analyses have (...) no such implication. In this paper I will show that the most liberal of the reductionist theories, those Roderick Chisholm calls “latitudinarian theories”, are unacceptable.Latitudinarian analyses have been proposed by many philosophers, including Ernest Sosa, Mark Pastin, and also, perhaps, W. V. Quine and Wilfrid Sellars. (shrink)

Those who campaign for law reform to permit “euthanasia” may seek different things and at least some of what they seek may already be permissible under the criminal law of England and Wales. In this paper I examine one means whereby the criminal law delivers outcomes acceptable to the euthanasia lobby, that is the curious notion of “causation” deployed by the law, which adds a value override to the more usual notion of factual causation such that, for example, if medical (...) treatment falls within the acceptable range as normal and proper, the pre–existing injury or illness is treated as exclusively the cause of death and the doctor escapes criminal liability, even where the medical treatment will shorten life to the certain knowledge, possibly even the wish, of the doctor. Thus the law may already be delivering a range of outcomes — euthanasia in a weak sense — acceptable to the euthanasia lobby. If so, it achieves this by stealth. That is inappropriate to the doctor–patient relationship, which is one of trust. So there is a strong case for greater transparency. Moreover, there are limits to the acceptable outcomes which an unreformed criminal law can deliver and in a range of cases the criminal law condemns the doctor to impotence and the patient to a prolonged, miserable and undignified death. So there is also a case for going beyond the current law and legalising euthanasia in a strong sense. (shrink)

A review, with reflections, of Michael S. Gazzaniga's (2011) book, Who's in Charge? Free Will and the Science of the Brain. Gazzaniga, a distinguished neuroscientist, wishes to connect contemporary understandings of the functioning of the human brain to the proper functioning of the American courtroom. What effect, if any, should these current understandings (and current technologies) have on legal conceptions of personal responsibility, guilt, and punishment? If, as many neuroscientists hold, the functioning of the brain wholly determines the functioning of (...) the mind, can people rightly be held responsible for their actions? Gazzaniga argues that they can. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:86 HISTORY OF PHILOSOPHY he solved the problem of his own existence, this picture of an erudite scholar systematically and unemotionally peeling off the foibles of the learned world as the only solution for the perplexing problems of the life, seems credible and direct. Since the essay presenting it is brilliantly written, with some of Bayle's own penetrating analyses, we can be sure that it will have its day (...) in court. Is it out of place to announce with this review that the Soc/$tg Arigdoise des science, lettres, e$ arts has purchased the house where Bayle was born at Carla-Bayle, and plans to make it into a monument-museumhonoring the philosopher? The house is in bad repair and there is a great need for funds; gifts of any size may be sent to the Socigtd, C.C.P. Toulouse 114-19, France. I presume that they are deductible. JoH~ B. WOLF University o] Illinois, Chicago Circle Entretiens sur les sciences. By Bernard Lamy. Edition critique pr~sent~e par FranCois Girbal & Pierre Clair. (u 5 of the series Le mouvement des idJes au XVII ~ si~cle) (Paris, 1966.Pp. 448. F 36.--) Father Bernard Lamy, 1640-1715, an Oratorian who was a contemporary of Malebranche, wrote his Entreticns sur les sciences not for the savants but for young gentlemen of the time who might have wanted to enter into the intellectual world. The work was first written be= tween 1676-80, and published by 1684. It developed through three stages in Lamy's lifetime, and was a popular exposition of modem learning throughout the eighteenth century. (It was last published in French in 1768, and in Spanish in 1800.) Drs. Clair and Girbal have provided a most useful edition of this minor classic, giving the variants from the different versions done by Lamy. The editors, who know the Oratorian and Jansenist currents of the time well, have included lots of informative notes. In these they have stressed the possible influence of Lamy's text on two of its important readers, Montesquieu and Rousseau, providing many clues to be followed out. The editors have also republished in their introduction the original review of Lamy's work by Pierre Bayle from the Nouvells de la R$publique des Lettres of August, 1684. The Entretien8 should be of interest to anyone concerned with late seventeenth-century thought. Although Lamy was not a particularly original thinker, his presentation of what was known provides an important picture of the world of learning of his time. Lamy was a Malebranchist first of all, tremendously impressed by the metaphysics and epistemology of his colleague, by the relevance of this philosophy to mathematical and scientific studies, and by the religious orientation of Malebranche's scientific thought. Lamy was also a Cartesian with re= gard to method and logic, greatly influenced by Amauld's and Nicole's Port-Royal Logic. But Lamy was also an eclectic who saw merit in the empirical work of his time, admiring Gassendi's efforts as well as those of Galileo, Boyle and of the Royal Society. For Lamy there should be no conflict between science and religion. A good deal of the Entreticns is devoted to explaining what mathematics and the sciences are about, and how they should be studied. Lamy was a great advocate and popularizer of the 'new science', the mechanistic approach from Galileo down to Malebranche and Newton. For him scientific study should lead to a better understanding of the Divine World. "Nous lotions la Science... lots qu'elle est plac6es dans une gme qui aime Dieu, qui est la v6rit6, & par consequent le v6ritable objet de la Science" (p. 47). In a world in which it is alleged that science was at war with religion, Lamy along with his hero Malebranche, and the philosophical Jansenists, sought not only for a harmony of the 'new science' and a Christian world view, but for the religious use of this science in a religious understanding of the world. Lamy's presentation, in an unexciting dialogue form, reveals many interesting facets of both his own outlook as well as of that of his contemporaries. Lamy's Cartesian methodology clearly shows the... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 461 Whitehead moved beyond classical accounts of "points" and "instants" toward a relativistic understanding of space/time. Lowe is cautious about reading too much of the later thinking into the pre-191o writings. Whitehead's interest in philosophy was satisfied mainly through his discussions with fellow members of the Cambridge Apostles who met regularly to discuss issues of a general nature. Among the Apostles McTaggart stands out as having had (...) the most important influence on Whitehead's philosophical development. McTaggart 's staunch neo-Hegelianism served as a stimulus to Whitehead but he retained an independent outlook throughout. Readers of Process and Reality will be interested in Lowe's treatment of Whitehead's flirtation with Roman Catholicism and his subsequent agnosticism during the last decade of the nineteenth century. By 19~5 he had regained his theism and found a place for it in his system. Much care is given to the collaboration with Russell on Principia Mathematica during the first decade of the new century. Lowe corrects the oft-held belief that Whitehead let Russell do most of the work on the text. By a careful study of the correspondence, Lowe shows that Whitehead continually guided the joint enterprise toward more detailed proofs and elaborations. Russell frequently remained content with truncated arguments for his fundamental logical principles. Whitehead demanded that each argument receive sufficient articulation so as to enhance the pedagogical value of the work. Russell's atomic pluralism, which insisted that all relations were external to their relata, never appealed to Whitehead. During the period of the Principia, Whitehead chose to ignore that aspect of Russell's perspective. One difficult dimension of this decade-long collaboration is Russell's alleged affair with Evelyn Whitehead. Lowe argues that this relationship was never consummated even though Evelyn was and remained one of the three great loves of Russell's life. Whitehead somehow managed to overlook what must have been an obvious threat to the integrity of his marriage. Lowe's brilliant and definitive account in this first volume of a two-volume work brings us to the Whiteheads' move from Cambridge to London. Difficulties with University officials and a need for larger horizons compelled Whitehead to emerge from the cozy atmosphere of Trinity College where he had spent thirty highly creative years working on the frontiers of mathematics and logic. The second volume will take us from the years in London to Whitehead's life at Harvard, and should, no doubt, be as rich and insightful as the first. ROBERT S. CORRINGTON The Pennsylvania State University Allan Janik. Essays on Wittgenstein and Weininger. Studien zur OsterreichischenPhilosophie, Band 9. Amsterdam: Rodopi B.V., 1985. Pp. 161. Paper, $18.95. In 1973, Allan Janik and Stephan Toulmin published Wittgenstein's Vienna in which they explored the intellectual atmosphere of the city in which Wittgenstein grew to intellectual maturity. Both Toulmin, who had been a student of Wittgenstein's at 46~ JOURNAL OF THE HISTORY OF PHILOSOPHY ~5:3 JULY 1987 Cambridge, and Janik, who was interested in Wittgenstein and Schopenhauer, suspected that Wittgenstein might more accurately be seen as a Viennese intellectual dealing with the problems pervading the late Habsburg empire than simply as the successor of Frege and Russell who comes to dominate English and American philosophy. In the section on method in Wittgenstein's Vienna, Janik and Toulmin carefully avoided claiming that their picture of Wittgenstein and Vienna explained the Tractatus or the Philosophical Investigations, but they suggested that Wittgenstein is more intelligible as both a man and a thinker when viewed against his complete historical context, rather than when he is seen solely as a misfit in Cambridge in his last years. Janik has continued exploring themes connected with pre-World War I Austrian philosophy and has emphasized the connection between thinkers in this milieu with the new image of Wittgenstein which is emerging from the wealth of Wittgensteiniana now appearing. The present volume is a group of non-consecutive essays written from 1966 to 1984 in which Janik argues in favor of recognizing Austrian philosophy as something to be understood in terms of the special circumstances of the late Hapsburg empire and its demise. One of its... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:264 HISTORY OF PHILOSOPHY right at hand, without getting in the way. If it had been printed in as readable type and as elegant form as Steinmann's edition, it might be the ideal easily accessible version to familiarize us with the Pens~es as they were actually written and classified by Pascal himself. RICHARD H. POPKIN University of California, San Diego Pascal. Quinta edizione riveduta e aumentata. By Michele (...) Federico Sciacca. (Milano: Carlo Marzorati Editore, 1962. Pp. 250. 2000 L.) This Pascal by Sciacca consists of three parts. The first gives and considers the Life of Pascal (1623-1662) in connection with his complex and restless century (pp. 13--72). The second part (pp. 75-112) analyzes the relationship of Pascal with Jansenism. Pascal is both dependent on and independent of it. The Jansenists discussed while Pascal felt. Jansenism could not find a stable equilibrium between nature and grace which Jansenism either contrasted or confused while Pascal well distinguishes these two orders. They are for him heterogeneous but the lower order leads to the higher. Without God, man is misery and darkness. With God, man can do all things (p. 118). The third part (pp. 115-219) is entitled The Christian Philosopher. It shows that man is made for the infinite. The true call of humanity is religious (p. 206). The final conclusion is that Pascal can still teach us to exist (p. 216). PAUL Y. FUHRMANN Columbia Theological Seminary Louis Thomassin (1619-95), ~tude bio-bibliographique avec vingt lettres et deux textes in~dits. By Pierre Clair. (Vol. I of the series Le mouvement des idles au XVH" si~cle, Collection dirig~e par Andr~ Robinet.) (Paris: 1964. Pp. 160. NF 12.) This small volume is the first in a new series devoted to bringing to light various figures and aspects of seventeenth-century thought that have either been set aside, forgotten, or are only dimly known. Louis Thomassin (as well as Bernard Lamy who is the subject of the second volume that has appeared in this series) certainly falls in these categories. Although his name often turns up in discussions of Cartesianlsm, Jansenism, Malebranchism, etc., very little consideration is ever given to him as a fairly important personage of the time, or to his ideas and the role they played. This volume by Dr. Clair will be of much use to seventeenth-century scholars in providing the basic data about his life, his connections with several of the vital movements of the period, the fundamental bibliographical materials, as well as publishing two texts and twenty letters not before available. The biographical section (pp. 1-84) traces (a bit too episodically) Thomassin's education, his career among the Oratorians as a professor of humanities, philosophy, and theology, his possible involvements with the Jansenists, his difficulties as a result of his first published work, Dissertations sur les Conciles (1667) (suppressed the same year), his later successes for his many other works in theology, philosophy, history, and pedagogy, and his relations with various major and minor figures of the mid- and late seventeenth century, like Arnauld, Malebranche, Richard Simon, Bayle, Huet, etc. Section II (pp. 85-99) gives a detailed bibliography of Thomassin's published works, plus a list of his manuscripts located in various French libraries. This is followed by twenty letters of Thomassin, an intriguing and interesting discourse on the difference between history and science, and one on the nature of chronology, plus three letters by Thomassin's secretary, Nicolas Barat. In a brief BOOK REVIEWS 265 concluding chapter (pp. 150-52), Dr. Clair deals with "Comment lire l'oeuvre du P. Thomassin," providing much guidance to anyone who wishes to avail himself of the rich resources in Thomassin's writings. From the point of view of the history of philosophy, the most interesting aspects of Thomassin's thought seem to be (1) his "Cartesianism," that is, the extent to which he early imbibed Descartes' new ideas, and played a role in the fusion of the views of Augustine, B6rulle, and Descartes that developed in the Oratory, (2) his attempt to find a viable theory of the nature of Grace somewhere between Arnauld and Malebranche, and (3) his... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 453 PAUL HENRY (19o6-1984) Paul Henry was a renowned scholar of Plotinus and Neo-Platonism. Born in Louvain, the son of a chemistry professor at the university there, he was sent to school in England during World War I. He then returned to Belgium, and studied philosophy and theology at Louvain, and joined the Society of Jesus. He did further studies in Paris in Middle Eastern culture, and (...) studied Arabic in Syria, Lebanon, and Palestine. In Rome he did further studies and received an S.T.D. from the Pontifical Gregorian University, as well as a Licentiate in Sacred Scripture from the Pontifical Gregorian University. He was appointed professor at the Institut Catholique in Paris. He published several fundamental studies on Plotinus and the development of NeoPlatonism in Western thought. He and Hans Rudolf Schwyzer of Zurich collaborated on the critical edition of Plotinus's Enneads,and he and his former student, Pierre Hadot, produced the critical edition of the theological treatises of Marius Victorinus. Paul Henry made his first visit to the United States in 1952 where he was a visiting professor at Fordham. At a meeting of the American Philosophical Association that year he met Richard Popkin. They became close friends. This led to Henry being invited to be a visiting professor at the University of Iowa, to give the Foster lecture on the immortality of the soul at the University of California, Berkeley, and to his later being appointed a regular professor at the University of California, San Diego. He also was a visiting professor at the University of Pennsylvania, Duke, Northwestern, the College of New Rochelle and St. John's University in New York. Paul Henry was an important consultant and adviser to the JournaloftheHistoryofPhilosophy in its early years. With his vast erudition, his understanding of the different kinds of scholarship being undertaken in Europe and America, in Catholic and non-Catholic institutions, he was able to assist us in finding the best scholarly articles, the best referees and reviewers of materials in many fields. Paul Henry was a person of immense charm, vivacity and humanity. He was able to break down barriers between people of differing backgrounds, and to form deep, abiding friendships with students and scholars all over the world. He took great interest in a variety of ventures to increase learning and understanding in intellectual history. His concerns ranged from early Christian thought, pagan Neo-Platonism, the fusion of the two in Victorinus and Augustine, up to leading intellectual ideas in modern European thought such as the structuralism of LeviStrauss and the theology of Teilhard de Chardin. He encouraged young and maturing scholars in America and Europe, and tried to bring out the very best of their abilities. He encouraged the understanding of different thought systems, the appreciation of their strengths and weaknesses. And, perhaps as much as any one in the post-second-World-War period, he encouraged frank and open discussions between Catholic and non-Catholic scholars, and thereby built many bridges. Those who knew him have profited immensely from his learning, wisdom and humanity. Those who worked to launch and develop the Journal are especially grateful for his help and support in the early days of this venture. We hope that his scholarship will encourage many others to develop fresh understandings of Neo-Platonism and its importance in the philosophical, theological and scientific world, from ancient times to the present. He will be sorely missed, but he has left a great legacy to those working in the history of philosophy. RICHARD H. POPKIN... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:NOTES AND DISCUSSIONS Shadow History tl9 Richard Watson's essay looks as if it is breaking new ground, but on re-re-reading it, it seems to me that several incommensurable and unrelated problems and phenomena are being treated together. If separated into constituent parts, there may be less here than meets the eye. First of all, the phenomenon of "shadow history," and its role as foundation for a philosophy or (...) a philosophical position goes back, I think, at least to Aristotle's account of his predecessors, especially of his teacher, and beyond that perhaps to Plato's account of the Sophists. It appears in Maimonides's account of Arabic occasionalism, which was used to justify medieval Aristotelianism (and this account was accepted uncritically by Leibniz, Malebranche, and others in the seventeenth century). Bacon's, Descartes's, and Locke's presentation of Scholasticism is definitely "shadow history" that was used as the start of the "new" way of ideas, and as its justification.. Hegel's view of the history of philosophy is another major "shadow history." Hence the fact that Russell, Ayer, Ryle and Rorty adopted similar strategies of using a spurious or dubious history of their predecessors is not so strange. Any historian of philosophy worth her or his salt is aware that historical philosophical personnages have used their own views of their predecessors' philosophies as ways of making their own "original" philosophical views more exciting or important or credible. We have learned long ago how to separate the alleged past from the historical past, and even to see that the alleged past plays a significant role in the writings of various philosophers. Watson has put it neatly in his four examples, but these are only intriguing because so litde history of analytic philosophy has been written up to this time. We have much, maybe too much, literature about how Kant misrepresented Hume, Hume misrepresented Berkeley, etc. In the decades to come we may have much about Russell, Ayer, Ryle and Rorty as misrepresenters. Then, Watson's point can help separate the charge that they were poor historians from the realization that they used history creatively as "shadow history." And we may even have historical evidence from the Russell papers and other archives that they knew full well what they were doing, and were not pretending to be good historians, or, on the other hand, that they themselves did not realize they were writing "shadow history," but thought they were actually real historians. Watson tries to make the activity of creating "shadow history" a challenge to historians of philosophy, and a plus for the creative philosophers. In the cases he discusses the "shadow histories" have had great influence on the development of twentiethcentury philosophy in England and America. Even though I am a sceptic, I have no doubt that historians of Anglo-American philosophy will explore his points, and distinguish the "shadow histories" from the best available historical interpretations of what previous philosophers said and meant. Both interpreting and understanding the "shadow histories" and the best available histories will change and develop depending on future interests and information. Watson uses "historians" without really making clear who he is talking about. Only three people are mentioned: Gregor Sebba, Etienne Gilson and Paul Oskar Kristeller. 120 JOURNAL OF THE HISTORY OF PHILOSOPHY 31 : 1 JANUARY 1993 There are many others who consider themselves historians of philosophy, or are considered as such in the profession; I doubt that they are all as objectivist as Watson thinks, believing that they can ascertain exactly what happened in the past. But I think most of us share a view that we can do better or worse at this, depending on materials and techniques used, perspectives employed, etc. Almost all of us would contend that being able to read the basic source material in the original language and being able to understand it in context, yields a better understanding of what a historical philosopher said and meant. Watson appears to agree, but then says this does not matter, because a "shadow history" may be longer remembered and used in creative philosophy than a historian's history. The example he offers is that of Yolton's Locke... (shrink)

Conformity is a large topic and its causes are undoubtedly heterogenous. Of the various mechanisms that contribute to conformity, I will comment on two: coordination and esteem. Game theorists have given coordination significant attention. Lewis first posited that social conventions are, roughly, particular equilibrium outcomes to recurrent coordination problems. Once the equilibrium occurs, it is, by definition, in everyone’s interest to conform. Evolutionary game theorists have explored the conditions that make a certain equilibrium likely to emerge and persist when more (...) than one equilibrium is possible. In the first section below, I set forth one point about the nature of conformity in such settings—that there can be a strong stability to conventions in which the required behavior varies by the observable physical differences among human beings, such as sex and those that come to be associated with race. In a certain class of important games, observable personal differences work to “break symmetry,” which significantly changes the possible outcomes to the game. My aim is not to provide a particular model of conformity involving sex and race, but to illustrate the usefulness of a particular approach to model-building. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:212 HISTORY OF PHILOSOPHY with Gassendi and his studies on atomism. Yet Papi gives us very little which is not already generally known. There is but a mere hint of how atomistic philosophy was handled by the Aristotelians and to what extent they actually absorbed some of that tradition themselves. Nothing in detail is said of the process whereby atomistic and Platonic motives became coupled, not only by Bruno, (...) but by Ficino before and by Cudworth afterwards. On the credit side, however, the author does call attention to the commentary and paraphrase of Lucretius by Girolamo Frachetta of Rovigo (printed 1589), a work of some interest, which has been but little studied. Such rays of light are all too infrequent in this section and Papi is usually content to follow the conventional beaten path. For one to write a book on Bruno which breaks new ground is now difficult, for the field has been so thoroughly worked over. This one takes up a number of interesting themes found in Bruno's writings and sheds some light on them, but it seldom if ever says anything very different from the well-established tradition of Bruno scholarship in Italy which has produced so many mediocre books over the years. The specialist on Bruno and the sixteenth century will find little to detain him; the more casual reader could be ~rected to a number of superior treatments of various aspects of the Nolan's thought. In short, this study adds but little to what is already known. CHAm~V_SB. ScH~rrr University of Leeds Sir Walter Ralegh dcrivain, l'~uvre et les iddes. By Pierre Lefranc. (Qutbec: Les Presses de l'Universit~ Laval, 1968. Pp. 733. $19.50) This excellent study, the fruit of more than a dozen years of research, throws much light on Ralegh's thought and literary achievement. Lefranc has examined the manuscript sources, and unearthed quite a few new ones, and has patiently, carefully, and with much detective work, established what is no doubt the best available hypothesis of what is authentic among Ralegh's purported prose and poetic writings, and the date and circumstances of their composition. He has analyzed them in the context of Ralegh's carver, and has developed an exciting and rich interpretation of his political, philosophical and religious ideas. Ralegh's role in intellectual history derives mainly from his reputation as a Machiavellian, as an atheist, and from his mammoth, "pious," much-read providential History of the World (written during his years as a prisoner in the Tower of London). Lefranc deftly sorts and weighs the evidence for the various views and attitudes attributed to Ralegh in his own day and by interpreters ever since, and emerges from this examination with a fresh and striking picture of one of the liveliest bridge figures between the Elizabethan Renaissance and the modern world. The establishment of the canon leads to discarding as not by Ralegh many writings that have previously been used in interpreting the courtier's views. Three philosophical works which have played a role in twentieth-century interpretation, "A Treatise of the Soule," "The Prince, or Maxims of State" and "The Sceptick" are shown to be doubtful to a greater or lesser degree. "The Sceptick," which Strathmann (Sir Walter Ralegh,,4 Study in Elizabethan Skepticism, New York, 1951) had used to interpret Ralegh as a sceptical-Christian fideist, had been questioned earlier by Lefranc, Sprott, and myself. It is just a translation of portions of Book I of Sextus F_znpiricus' Outlinea of Pyrrhonism, and contains no connection with Ralegh, except that it was BOOK REVIEWS 213 published in his literary remains in 1651. Lefranc now, examining the evidence of the four manuscripts that have been discovered, concludes that it was a part of Ralegh's documentation when he was doing his research, but that 'Tattribution de 'The Sceptick' Ralegh lui-m~me ne repose sur rien" (p. 67). With the canon shorn of the dubious items, Lefranc proceeds to unfold a picture of Ralegh's intellectual world. As a practical statesman, buccaneer and explorer, Ralegh had a view of the role England should play vis-,'t-vis Spain and the New World that contained... (shrink)

The main battles of the Pyrrhonists were not fought with Gassendi, but with the later followers of Cartesian rationalism. Pascal saw the Pyrrhonian view as invincible; all science was in doubt, if we appealed only to rational evidence. No axioms or principles could be found which were indubitable, and all one could conclude was that "Pyrrhonism is true." As long as there are dogmatists, the Pyrrhonists will conquer. Reason forces one to Pyrrhonism. Nature however refuses to let us doubt everything. (...) Only through God's grace can we get out of this predicament of being sceptics by reason and dogmatists by nature, and only through the mysteries of faith can we be saved from the crise pyrrhonienne. (shrink)

In patients with pain characterized by a painful focus and allodynia, the painful symptoms arise from altered central processing that is initiated and subsequently maintained by persistent input from nociceptive afferents. Treatments directed at this normal consequence of persistent input are inherently limited. The most efficacious treatments will target the pathology, the various sources of ongoing nociceptor input. [blumberg et al.; coderre & katz; dickenson].

Philosophy of mystery -- Do we create our own mysteries? -- Do we know anything at all? -- What is reality? -- Why is there something rather than nothing? -- Why is nature ordered? -- Reductionism and emergence -- Does science dispel mystery? -- What of current mysteries in physics and cosmology? -- What of current mysteries in biology? -- What am i? -- What is consciousness? -- Do we have free will? -- Does god exist? -- Is there an (...) objective meaning to our lives? -- The mystery of the ordinary. (shrink)

Read epugugnomenou just as prosbalonton has been corrected. The rain was still falling.7. 2. Two points may be urged against the MS. reading. First Lake-daimonious epetakthe is an extremely awkward construction, if it means that they gave, not received, the order. In Thucydides the dative is quite rare in this use with passives, except of course with perfect tenses, and the cases in which it most often occurs will not be compared with this by any competent scholar . But special (...) awkwardness arises from the fact that epitatto naturally takes a dative of a quite different kind, and that in this sentence such a dative is actually added. (shrink)

Read epugugnomenou just as prosbalonton has been corrected. The rain was still falling.7. 2. Two points may be urged against the MS. reading. First Lake-daimonious epetakthe is an extremely awkward construction, if it means that they gave, not received, the order. In Thucydides the dative is quite rare in this use with passives, except of course with perfect tenses, and the cases in which it most often occurs will not be compared with this by any competent scholar. But special awkwardness (...) arises from the fact that epitatto naturally takes a dative of a quite different kind, and that in this sentence such a dative is actually added. (shrink)

7. 2. Two points may be urged against the MS. reading. First S0009838800015366_inline3 is an extremely awkward construction, if it means that they gave, not received, the order. In Thucydides the dative is quite rare in this use with passives, except of course with perfect tenses, and the cases in which it most often occurs will not be compared with this by any competent scholar. But special awkwardness arises from the fact that S0009838800015366_inline5 naturally takes a dative of a quite (...) different kind, and that in this sentence such a dative is actually added. (shrink)

Vaccine research, as well as the development, testing, clinical trials, and commercial uses of vaccines involve complex processes with various biological data that include gene and protein expression, analysis of molecular and cellular interactions, study of tissue and whole body responses, and extensive epidemiological modeling. Although many data resources are available to meet different aspects of vaccine needs, it remains a challenge how we are to standardize vaccine annotation, integrate data about varied vaccine types and resources, and support advanced vaccine (...) data analysis and inference. To address these problems, the community-based Vaccine Ontology (VO) has been developed through collaboration with vaccine researchers and many national and international centers and programs, including the National Center for Biomedical Ontology (NCBO), the Infectious Disease Ontology (IDO) Initiative, and the Ontology for Biomedical Investigations (OBI). VO utilizes the Basic Formal Ontology (BFO) as the top ontology and the Relation Ontology (RO) for definition of term relationships. VO is represented in the Web Ontology Language (OWL) and edited using the Protégé-OWL. Currently VO contains more than 2000 terms and relationships. VO emphasizes on classification of vaccines and vaccine components, vaccine quality and phenotypes, and host immune response to vaccines. These reflect different aspects of vaccine composition and biology and can thus be used to model individual vaccines. More than 200 licensed vaccines and many vaccine candidates in research or clinical trials have been modeled in VO. VO is being used for vaccine literature mining through collaboration with the National Center for Integrative Biomedical Informatics (NCIBI). Multiple VO applications will be presented. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 149 On the other hand, "a history which were only a lofty generalisation would go astray in pure speculation and would deduce its content from principles without making sure that the bulk of facts produced in reality could find its proper place within its frame" (ibid.). Hence, between the anecdotic and fantastic, history asserts its own exigencies, which are authenticity and intelligibility expressed in a true system (...) of human evolution. In the last chapter of Part I, Callot makes interesting observations concerning the problem of prevision or prediction in history. He mentions two types, the long4erm and the shortterm type, which he calls the type of prediction on the basis of history of philosophy, and the type of prediction on a sociological basis, respectively (p. 216). As is well known, Hegel developed his dialectical method in a constructive critique of Kant's doctrine of antinomies. In his Encyclopgdie, he observes that Kant's discovery of the inevitability of antinomies is "one of the most important and profound developments in modern philosophy." This association of ideas invites certainly to a further constructive critique and should be discussed in a book whose main subject is the antinomies in history. Furthermore, Marx's contribution to the development of dialectic and, in particular, his doctrine of "contradictions " as presented in Capital is far too important to be passed over in silence. The connection between Marxian dialectic and the Correspondence principle in physics (Bohr), to which Callot seems to refer on page 264, is so obvious that it should not be neglected in a book which otherwise bears testimony of erudition and intrepidity. I quite agree with Fernand Braudel that the author owes us another volume where the thinking of Marx and his historiographical descendants up to Jean-Paul Sartre's Critique de la raison dialectique is closely scrutinized. By taking such a step, Callot would probably create a still more suitable basis for the discussion of the problems of history of philosophy and science, of which he, in Part II of the book, gives an instructive and lengthy report. JOHANNES WI~-HANSEN University of Copenhagen BOOK NOTES New Editions Pierre Bayle, Oeuvres diverses, I. Avec une introduction par Elisabeth Labrousse. Hildesheim, C~eorge Olms, Verlagsbuchhandlung, 1964. xx -{- 760 pp. Subscription price per volume, DM 118. (Individual volumes, DM 148.) In view of the revival of interest in Pierre Bayle's thought and influence, it is fortunate that this excellent photoreproduction edition of his Oeuvres diverses, which have been so difficult to obtain, will now again be available. The four volumes, published first in 1727, bring together all of Bayle's works other than the Dictionnaire historique et critique, plus many of his letters. The present photoreproduetion edition will include all the works except the letters, since a new edition, including a very large number of those not in the Oeuvres diverses is now being prepared by a group of scholars under the direction of Madame Labrousse for the International Archives of the History of Ideas series. The first volume consists of the issues of the Nouvelles de la Republique des Lettres during Bayle's editorship, from its inception in 1684, until Bayle withdrew because of illness in 1687. Madame Labrousse, in her fine Introduction, discusses the history of this journalistic venture, and its importance in European intellectual history. The flight of so many French refugees to the Netherlands made it possible to set up a journal in Holland, written in French, that would review works in theology, philosophy, natural science, mathematics, history, etc. The capital, the publisher, the printers, the author and most of the readers were all refugees from Louis XIu persecutions. Bayle, while teaching philosophy at the ]~cole illustre of Rotterdam and writing some of his famous works, like the Ce que c'est la France toute catholique and Commentaire philosophique, undertook to review what was going on in the Republic of Letters. His objectivity, erudition, wit, and critical ability made the effort a success, and led to the series of other efforts, such as Jean Le Clerc's Bibliotheque choisie, and Henri Basnage de Beauval's Histoire des ouvrages des Sgavans. Bayle discussed the issues of the day--the... (shrink)

_Heidegger_ is a classic introduction to Heidegger's notoriously difficult work. Truly accessible, it combines clarity of exposition with an authoritative handling of the subject-matter. Richard Polt has written a work that will become the standard text for students looking to understand one of the century's greatest minds.

The Cell Ontology (CL) is designed to provide a standardized representation of cell types for data annotation. Currently, the CL employs multiple is_a relations, defining cell types in terms of histological, functional, and lineage properties, and the majority of definitions are written with sufficient generality to hold across multiple species. This approach limits the CL’s utility for cross-species data integration. To address this problem, we developed a method for the ontological representation of cells and applied this method to develop a (...) dendritic cell ontology (DC-CL). DC-CL subtypes are delineated on the basis of surface protein expression, systematically including both species-general and species-specific types and optimizing DC-CL for the analysis of flow cytometry data. This approach brings benefits in the form of increased accuracy, support for reasoning, and interoperability with other ontology resources. 104. Barry Smith, “Toward a Realistic Science of Environments”, Ecological Psychology, 2009, 21 (2), April-June, 121-130. Abstract: The perceptual psychologist J. J. Gibson embraces a radically externalistic view of mind and action. We have, for Gibson, not a Cartesian mind or soul, with its interior theater of contents and the consequent problem of explaining how this mind or soul and its psychological environment can succeed in grasping physical objects external to itself. Rather, we have a perceiving, acting organism, whose perceptions and actions are always already tuned to the parts and moments, the things and surfaces, of its external environment. We describe how on this basis Gibson sought to develop a realist science of environments which will be ‘consistent with physics, mechanics, optics, acoustics, and chemistry’. (shrink)

This volume is a comprehensive roadmap to the burgeoning area of affective sciences, which now spans several disciplines. The Handbook brings together, for the first time, the various strands of inquiry and latest research in the scientific study of the relationship between the mechanisms of the brain and the psychology of mind. In recent years, scientists have made considerable advances in understanding how brain processes shape emotions and are changed by human emotion. Drawing on a wide range of neuroimaging techniques, (...) neuropsychological assessment, and clinical research, scientists are beginning to understand the biological mechanisms for emotions. As a result, researchers are gaining insight into such compelling questions as: How do people experience life emotionally? Why do people respond so differently to the same experiences? What can the face tell us about internal states? How does emotion in significant social relationships influence health? Are there basic emotions common to all humans? This volume brings together the most eminent scholars in the field to present, in sixty original chapters, the latest research and theories in the field. The book is divided into ten sections: Neuroscience; Autonomic Psychophysiology; Genetics and Development; Expression; Components of Emotion; Personality; Emotion and Social Processes; Adaptation, Culture, and Evolution; Emotion and Psychopathology; and Emotion and Health. This major new volume will be an invaluable resource for researchers that will define affective sciences for the next decade. (shrink)

The Responsible Self was H. Richard Niebuhr's most important work in Christian ethics. In it he probes the most fundamental character of the moral life and it stands today as a landmark contribution to the field. The Library of Theological Ethics series focuses on what it means to think theologically and ethically. It presents a selection of important and otherwise unavailable texts in easily accessible form. Volumes in this series will enable sustained dialogue with predecessors though reflection on classic (...) works in the field. (shrink)

Social scientists and data analysts are increasingly making use of Big Data in their analyses. These data sets are often “found data” arising from purely observational sources rather than data derived under strict rules of a statistically designed experiment. However, since these large data sets easily meet the sample size requirements of most statistical procedures, they give analysts a false sense of security as they proceed to focus on employing traditional statistical methods. We explain how most analyses performed on Big (...) Data today lead to “precisely inaccurate” results that hide biases in the data but are easily overlooked due to the enhanced significance of the results created by the data size. Before any analyses are performed on large data sets, we recommend employing a simple data segmentation technique to control for some major components of observational data biases. These segments will help to improve the accuracy of the results. (shrink)

In a recent discussion about how scientific knowledge might potentially change our understanding of the nature and extent of human genetic, cultural, or biological variation, the sociologist David Skinner identified two competing visions of the future: one that was decidedly dystopian, which conjured up a “re-racialized” future, and an opposing utopian future in which the potential for racialized thinking might be finally overcome. We can situate the ongoing debates about the congestive heart failure drug BiDil, approved by the Food and (...) Drug Administration for use only by African Americans, in relation to these differing future prospects.When the FDA announced its approval of BiDil in June 2005, it located the drug, and perhaps the future of pharmaceutical development, within a particular vision of the future, heralding BiDil as “representing a step toward the promise of personalized medicine.” The discourse of “personalized medicine” can be characterized as part of a utopian future, one in which clinicians will be able to make increasingly individualized decisions based on each patient’s genetic makeup so that the drugs they take will be those that work best for them. (shrink)

> Wealthy nations must do much more, much faster. The United Nations General Assembly in September 2021 will bring countries together at a critical time for marshalling collective action to tackle the global environmental crisis. They will meet again at the biodiversity summit in Kunming, China, and the climate conference 26) in Glasgow, UK. Ahead of these pivotal meetings, we—the editors of health journals worldwide—call for urgent action to keep average global temperature increases below 1.5°C, halt the destruction of nature (...) and protect health. Health is already being harmed by global temperature increases and the destruction of the natural world, a state of affairs health professionals have been bringing attention to for decades.1 The science is unequivocal; a global increase of 1.5°C above the preindustrial average and the continued loss of biodiversity risk catastrophic harm to health that will be impossible to reverse.2 3 Despite the world’s necessary preoccupation with COVID-19, we cannot wait for the pandemic to pass to rapidly reduce emissions. Reflecting the severity of the moment, this editorial appears in health journals across the world. We are united in recognising that only fundamental and equitable changes to societies will reverse our current trajectory. The risks to health of increases above 1.5°C are now well established.2 Indeed, no temperature rise is ‘safe’. In the past 20 years, heat-related mortality among people aged over 65 has increased by more than 50%.4 Higher temperatures have brought increased dehydration and renal function loss, dermatological malignancies, tropical infections, adverse mental health outcomes, pregnancy complications, allergies, and cardiovascular and pulmonary morbidity and mortality.5 6 Harms disproportionately affect the most vulnerable, including children, older populations, ethnic minorities, poorer communities and those with underlying health problems.2 4 Global heating is also contributing to the decline in …. (shrink)

__Culturally Responsive School Leadership_ focuses on how school leaders can effectively serve minoritized students—those who have been historically marginalized in school and society._ The book demonstrates how leaders can engage students, parents, teachers, and communities in ways that positively impact learning by honoring indigenous heritages and local cultural practices. Muhammad Khalifa explores three basic premises. First, that a full-fledged and nuanced understanding of “cultural responsiveness” is essential to successful school leadership. Second, that cultural responsiveness will not flourish and succeed in (...) schools without sustained efforts by school leaders to define and promote it. Finally, that culturally responsive school leadership comprises a number of crucial leadership behaviors, which include critical self-reflection; the development of culturally responsive teachers; the promotion of inclusive, anti-oppressive school environments; and engagement with students’ indigenous community contexts. Based on an ethnography of a school principal who exemplifies the practices and behaviors of culturally responsive school leadership, the book provides educators with pedagogy and strategies for immediate implementation. (shrink)

Many healthy volunteers choose to take part in Alzheimer’s disease prevention studies because they want to know whether they will develop dementia—and what they can do to reduce their risk—and are therefore interested in learning the results of AD biomarker tests. Proponents of AD biomarker disclosure often refer to the personal utility of AD biomarkers, claiming that research participants will be able to use AD biomarker information for personal purposes, such as planning ahead or making important life decisions. In this (...) paper, the claim that AD biomarkers have personal utility for asymptomatic individuals is critically assessed. It demonstrates that in the absence of clinical validity, AD biomarkers cannot have personal utility and do not serve research participants’ autonomy. Over the next few years, many research groups will be confronted with participants’ preferences to learn the results of AD biomarker tests. When researchers choose to make results available upon explicit request, they should ensure adequate information provision and education, notably on the uncertain clinical significance of AD biomarker information. Routine disclosure of AD biomarkers to cognitively unimpaired individuals in research settings cannot be justified with an appeal to the personal utility of AD biomarker information. (shrink)

Randomised placebo-controlled trials (RPCTs) are the gold standard for evaluating novel treatments. However, this design is rarely used in the context of orthopaedic interventions where participants are assigned to a real or placebo surgery. The present study examines attitudes towards RPCTs for orthopaedic surgery among 687 orthopaedic surgeons across the USA. When presented with a vignette describing an RPCT for orthopaedic surgery, 52.3% of participants viewed it as ‘completely’ or ‘mostly’ unethical. Participants were also asked to rank-order the value of (...) five different types of evidence supporting the efficacy of a surgery, ranging from RPCT to an anecdotal report. Responses regarding RPCTs were polarised with 26.4% viewing it as the least valuable (even less valuable than an anecdote) and 35.7.% viewing it as the most valuable. Where equipoise exists, if we want to subject orthopaedic surgeries to the highest standard of evidence (RPCTs) before they are implemented in clinical practice, it will be necessary to educate physicians on the value and ethics of placebo surgery control conditions. Otherwise, invasive procedures may be performed without any benefits beyond possible placebo effects. (shrink)

Objectives: To study the consent process experienced by participants who are enrolled in a molecular genetic research study that aims to find new genetic mutations responsible for an apparently inherited disorder.Design: Semi-structured interviews and analysis/description of main themes.Participants: 78 members of 52 families who had been recruited to a molecular genetic study.Results: People were well informed about the goals, risks and benefits of the genetic research study but could not remember the consent process. They had mostly been recruited to take (...) part by trusted clinicians or their relatives but had little memory of, or concern about signing consent forms. Families appeared to regard the research as a continuation of their, or their relatives’, clinical care.Conclusions: Ethical review should be more flexible in its attitude to consent forms and written information sheets for some sorts of research. For rare genetic disease studies where research has been discussed fully within the clinical setting then the consent obtained at that time could suffice rather than needing extra consent at a later stage. However, clinician-researchers will need to ensure that their duty of care extends for the duration of the research and beyond. (shrink)

Let be a relational system whereby D is a nonempty set and P1 is an m1-ary relation on D. With we associate the (weak) monadic second-order theory consisting of the first-order predicate calculus with individual variables ranging over D; monadic predicate variables ranging over (finite) subsets of D; monadic predicate quantifiers; and constants corresponding to P1, P2, …. We will often use ambiguously to mean also the set of true sentences of.

More's Latin reply to Bugenhagen, given here with a facing English translation, is a comparatively brief but intense rebuttal of the principal points of Lutheran teaching concerning scripture ant tradition, faith and works, grace and free will, clerical celibacy, and the sacraments. It presents arguments elaborated at much greater length in More's other polemical works. _Supplication of Souls_ refutes _A Supplication for the Beggars_, an anticlerical pamphlet by Simon Fish which Henry VIII seems to have regarded with some favor. More (...) places his response in the mouths of the souls in purgatory. In the first book, he contemptuously demolished Fish's loose railery with accurate statistics and historical analysis. In the second, he defends the traditional doctrine of purgatory with brief arguments drawn from reason and a detailed analysis of scriptural passages. _Letter against Frith_ answers John Frith's Zwinglian arguments against the physical presence of Christ in the more. Written to an unknown correspondent, it is the briefest and mildest of More's polemical works and anticipates arguments presented moer elaborately in More's _The Answer to a Poisoned Book_. Besides full introductions and commentaries, a glossary, and an index, this volume contains seven appendices giving the works to which More is replying and other thematic, historical, and bibliographical matter closely related to the three works by More. (shrink)

This paper describes the application of eight statistical and machine-learning methods to derive computer models for predicting mortality of hospital patients with pneumonia from their findings at initial presentation. The eight models were each constructed based on 9847 patient cases and they were each evaluated on 4352 additional cases. The primary evaluation metric was the error in predicted survival as a function of the fraction of patients predicted to survive. This metric is useful in assessing a model’s potential to assist (...) a clinician in deciding whether to treat a given patient in the hospital or at home. We examined the error rates of the models when predicting that a given fraction of patients will survive. We examined survival fractions between 0.1 and 0.6. Over this range, each model’s predictive error rate was within 1% of the error rate of every other model. When predicting that approximately 30°K of the patients will survive, all the models have an error rate of less than 1.5%. The models are distinguished more by the number of variables and parameters that they contain than by their error rates; these differences suggest which models may be the most amenable to future implementation as paper-based guidelines. (shrink)

Each contributor to this book has used personal experience as the basis from which to frame his individual sociological perspectives. Because they have personalized their work, their accounts are real, and recognizable as having come from 'real' persons, about 'real' experiences. There are no objectively-distanced disembodied third person entities in these accounts. These writers are actual people whose stories will make you laugh, cry, think, and want to know more.